This eBook shares information regarding the concept of disease development and its determinants. This concept primarily crucial for understanding multiple factors determine an individual to become a risk of getting a disease. There are uncounted environmental determinants, which are harmful to human health either proven via research or still under study. The linkage between these environmental determinants and disease outcomes become an interest in current monitoring and research to understand and estimate disease prevalence, early warning system and better health planning. However, this requires big data analysis; integrating various data and skill from multiple disciplines also carry a significant challenge in data management and analysis. The use of artificial intelligence is a brighter hope to fill this gap.